Recombinant Human 2B4/CD244 protein (His tag)

Abbreviation: 2B4;CD244

Target Synonym: Natural killer cell receptor 2B4;NK cell activation-inducing ligand;NAIL;NKR2B4;h2B4;SLAM family member 4;SLAMF4;CD244;2B4

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: C-His

UNIProt ID: Q9BZW8

Background: The CD244 antigen; also known as 2B4; is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating NK cell cytotoxicity and cytokine production; which is expressed on all NK cells; a subpopulation of T cells; monocytes and basophils. The 2B4 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor; human 2B4 can effectively activate and enhance NK cell–mediated cytotoxicity; induce secretion of IFN-γ and matrix metalloproteinases (MMPs); as well as NK cell invasiveness. As a cell surface glycoprotein of the Ig-superfamily structurally related to CD2-like molecules such as CD2; CD48; CD58; CD84; Ly-9; and SLAM; 2B4 (CD244) is expressed on all human NK cells; a subpopulation of T cells; basophils and monocytes. 2B4 activates NK cell mediated cytotoxicity; induces secretion of IFN-gamma and matrix metalloproteinases; and NK cell invasiveness.

Sequence: Met1-Arg221

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• SKU: ELSPDMH100145-100
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-PDMH100145-100
• Package Unit: 100 µg
• Quantity Unit: STK