Recombinant Human CD147/BSG/Basigin protein (His tag)

Abbreviation: CD147;BSG;Basigin

Target Synonym: Basigin;5F7;Collagenase Stimulatory Factor;Extracellular Matrix Metalloproteinase Inducer;EMMPRIN;Leukocyte Activation Antigen M6;OK Blood Group Antigen;Tumor Cell-Derived Collagenase Stimulatory Factor;TCSF;CD147;BSG

Target Species: Human

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: P35613

Background: CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer); also known as Basigin (BSG); is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis; embryo implantation; neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells; and thereby promotes invasion; metastasis; growth and survival of malignant cells. Furthermore; CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently; CD147 displays increased expression in many cancers; and it has been previously demonstrated to participate in cancer metastasis and progression. Thus; CD147 and its antibody are used as an effective treatment for malignant cancers.

Sequence: Glu 138-Ala 323

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• SKU: ELSPDEH100300-100
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-PDEH100300-100
• Package Unit: 100 µg
• Quantity Unit: STK