Abbreviation: CD62L;L-Selectin
Target Synonym: L-selectin;Sell;CD62 antigen-like family member L;Leukocyte adhesion molecule 1 (LAM-1);Leukocyte-endothelial cell adhesion molecule 1;Lymph node homing receptor;Lymphocyte antigen 22 (Ly-22);Lymphocyte surface MEL-14 antigen;CD62L
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-His
UNIProt ID: P30836
Background: L-Selectin (also known as Leukocyte Selectin, LAM?1, LECAM-1, LECCAM-1, TQ1, Leu-8, MEL-14 antigen, DREG, lymph node homing receptor, CD62L), a member of the Selectin family, is a cell surface glycoprotein expressed constitutively on a wide variety of leukocytes. Two forms of L?Selectin have been reported, apparently arising as a result of post-translational modifications. The lymphocyte form shows an apparent molecular weight of 74 kDa, while the neutrophil form is 90 - 100 kDa. Human and mouse L?Selectin share 76% amino acid (aa) sequence homology.L?Selectin plays a role in the migration of lymphocytes into peripheral lymph nodes and sites of chronic inflammation, and of neutrophils into acute inflammatory sites. Acting in cooperation with P-Selectin and E-Selectin, L?Selectin mediates the initial interaction of circulating leukocytes with endothelial cells that produces a characteristic "rolling" of the leukocytes on the endothelium. This initial interaction, also involving ICAM-1 and VCAM-1, leads eventually to extravasation of the white blood cell through the blood vessel wall into the extracellular matrix tissue.
Sequence: Trp 39-Asn 332
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
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