Abbreviation: CREB3L4
Target Synonym: Cyclic AMP-responsive element-binding protein 3-like protein 4;CREB3L4;cAMP-responsive element-binding protein 3-like protein 4;Androgen-induced basic leucine zipper protein (AIbZIP);Attaching to CRE-like 1 (ATCE1);Cyclic AMP-responsive element-binding pr
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-His & C-His
UNIProt ID: Q8TEY5
Background: The cyclic AMP responsive element-binding protein 3-like 4 (CREB3L4) is a transcription factor highly expressed in multiple human cancers. This study aimed to investigate the regulatory effects of CREB3L4 on GC progression and angiogenesis. CREB3L4 was overexpressed in GC tissues and cell lines, and was positively correlated with advanced tumor stage and poor survival in GC patients. The upregulation of CREB3L4 in GC cells increased cell viability, promoted cell proliferation, reduced apoptosis, enhanced cell migration and invasion, and induced the formation of tubule-like endothelial structures, whereas CREB3L4 knockdown impeded tumor cell growth, attenuated cell motility, and prevented human umbilical vein endothelial cells from forming tubule-like structures. In addition, mice inoculated with CREB3L4-deficient GC cells showed significantly suppressed tumor growth compared to the group harboring wild-type tumors.
Sequence: Glu 14-Ser 295
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
English
Deutsch
