Abbreviation: FGF18
Target Synonym: FGFI;zFGF5
Target Species: Human
Expression Host: E.coli
Fusion Tag: C-His
UNIProt ID: O76093
Background: Fibroblast Growth Factor 18 (FGF-18) is a 20 kDa protein that plays an important role in skeletal development and bone homeostasis . Mature human FGF-18 shares 99% amino acid sequence identity with mouse and rat FGF-18 . It is expressed in embryonic somites and the neural fold , adult lung , cerebellar and hippocampal neurons , hair follicle root sheath cells , and osteogenic mesenchymal cells . FGF-18 binds to FGF R2c, FGF R3c as well as the Golgi protein GLG1 and induces the proliferation of astrocytes and microglia, vascular endothelial cells, dermal fibroblasts, papilla cells, and keratinocytes . FGF-18 is required for normal skeletal development . It recruits osteoclasts and osteoblasts to the growth plate, promotes osteoclast formation and function, inhibits osteoblast differentiation, promotes skeletal vascularization, and induces chondrocyte hypertrophy and cartilage matrix formation.
Sequence: Val 31-Ala 207
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
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