Abbreviation: FGF23
Target Synonym: FGF-23;Fgf23;ADHR;FGF23;fibroblast growth factor 23;HPDR2;HYPF;phosphatonin;PHPTC
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-SUMO-His
UNIProt ID: Q9GZV9
Background: Fibroblast growth factor 23 (FGF?23) is a 30?32 kDa member of the FGF family, within a subfamily that also includes FGF?19 and FGF?21. FGF proteins contain a 120 amino acid (aa) core FGF domain that exhibits a beta ?trefoil structure. FGF?19 subfamily members are highly diffusible molecules owing to their poor ECM/heparin sulfate binding and plasma?stabilizing intramolecular folds. FGF?23 is produced by osteocytes and osteoblasts in response to high circulating phosphate levels, elevated parathyroid hormone, and circulatory volume loading. It functions as an endocrine phosphatonin by suppressing circulating phosphate levels . FGF?23 interaction with renal proximal tubular epithelium decreases the renal resorption of phosphate by down?regulating phosphate transporters and by suppressing vitamin D production. It also decreases the intestinal absorption of phosphate.
Sequence: Ala 24-Val 126
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
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