Recombinant human GDNF Protein(Trx Tag)

Protein Tag: N-Trx

Uniprot: P39905

Accession: P39905

Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing.

Bio Acitivity: Not validated for activity

Sequence: Arg109-Ile211

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin: < 10 EU/mg of the protein as determined by the LAL method.

Calculated MW: 31.2 kDa

Observed MW: 31 kDa

• SKU: ELSPDEH100497-1
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: PDEH100497-1
• Package Unit: 1mg
• Quantity Unit: STK
• Reactivity: Human
• Host: Escherichia Coli