Recombinant Human GITRL protein(His tag)

Abbreviation: GITRL

Target Synonym: Activation-inducible TNF-related ligand;AITRL;Glucocorticoid-induced TNF-related ligand;hGITRL

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: C-His

UNIProt ID: Q9UNG2

Background: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1.Promotes leukocyte adhesion to endothelial cells .Regulates migration of monocytes from the splenic reservoir to sites of inflammation.

Sequence: Leu49-Ser177

Purity: > 90 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• SKU: ELSPDMH100033-20
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-PDMH100033-20
• Package Unit: 20 µg
• Quantity Unit: STK