Description: IL-1α is a proinflammatory cytokine that is not secreted, it is produced by various cells like monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and share similar, if not identical, biological properties. These cytokines have diverse effects, including stimulating thymocyte proliferation by triggering IL-2 release, fostering B-cell maturation and proliferation, exhibiting mitogenic FGF-like activity, and prompting the release of prostaglandin and collagenase from synovial cells. However, there is a notable difference: IL-1β is secreted, while IL-1α primarily remains associated with cells. The recombinant Human IL-1α is an 18.0 kDa protein comprising 159 amino acid residues.
Expression System: E. coli
Molecular Weight: 18 kDa
Class: Recombinant
Endotoxin Concentration: <1 EU/µg
Activity: Determined by its ability to stimulate the proliferation of mouse D10S cells. The expected ED50 is ≤0.001 ng/ml, corresponding to a specific activity of ≥1 x 10^9 units/mg.
Form: Lyophilized
Contains: no preservative
Storage Conditions: -20°C
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses
Caution: For Research Use Only. Not for use in diagnostic procedures.
Gene Symbol: IL1A
Protein ID: P01583
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