Recombinant Human OLR1/LOX-1 protein (His tag)

Abbreviation: OLR1;LOX-1

Target Synonym: Oxidized Low-Density Lipoprotein Receptor 1;Ox-LDL Receptor 1;C-Type Lectin Domain Family 8 Member A;Lectin-Like Oxidized LDL Receptor 1;LOX-1;Lectin-Like oxLDL Receptor 1;hLOX-1;Lectin-Type Oxidized LDL Receptor 1;OLR1;CLEC8A;LOX1;LOXIN;SCARE1;

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: C-His

UNIProt ID: P78380

Background: Oxidized Low-Density Lipoprotein Receptor 1 (Ox-LDL Receptor 1) is a secreted; single-pass type II membrane protein which belongs to the C-type lectin superfamily. Ox-LDL Receptor 1 is expressed at high levels in endothelial cells and vascular-rich organs such as placenta; lung; liver; brain; aortic intima; bone marrow; spinal cord and substantia nigra. The expression of Ox-LDL Receptor 1 is induced by inflammatory cytokines such as TNF; IFNG and IL6 by pathological conditions; such as hyperlipidemia; hypertension and diabetes mellitus. Ox-LDL Receptor 1 mediates the recognition; internalization and degradation of oxidatively modified low density lipoprotein (OxLDL) by vascular endothelial cells. Ox-LDL Receptor 1 association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release; monocyte adhesion and apoptosis. Ox-LDL Receptor 1 also binds to oxLDL; which acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells; thereby participating in cell-mediated antigen cross-presentation. It also participates in inflammatory process; by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.

Sequence: Ser61-Gln273

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• SKU: ELSPDMH100077-20
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-PDMH100077-20
• Package Unit: 20 µg
• Quantity Unit: STK