Recombinant Human PPM1A protein (His tag)

Abbreviation: PPM1A

Target Synonym: Protein Phosphatase 1A;Protein Phosphatase 2C Isoform Alpha;PP2C-Alpha;Protein Phosphatase IA;PPM1A;PPPM1A;PP2C-ALPHA;PP2CA;PP2Calpha

Target Species: Human

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: P35813

Background: Protein Phosphatase 1A (PPM1A) is a member of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PPM1A has a broad specificity. PPM1A negatively regulates the activities of MAP kinases and MAP kinase kinases. Also; it negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3; resulting in their dissociation from SMAD4; nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. In addition; PPM1A can dephosphorylate cyclin-dependent kinases; and thus may be involved in cell cycle control.

Sequence: Gly2-Trp382

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• SKU: ELSPDEH100431-100
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-PDEH100431-100
• Green Labware: No
• Package Unit: 100 µg
• Quantity Unit: STK