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Encompassing Amino Acids: 67-406
Assay Conditions: Assay was performedusing BPS's Renin Assay kit, cat. # 80211, following the recommended assay protocol.
Background: Renin is a protease that is synthesized by the kidneys. Renin catalyzesthe hydrolysis of angiotensinogen to angiotensin I, which is converted to angiotensin II, ahighly potent vasoconstrictor. Renin inhibitors have been used therapeutically in thetreatment of hypertension (high blood pressure).
Description: Human Activated Renin (GenBank Accession No. NM_000537), amino acids 67 - 406 (end) with C-terminal HIS tag, MW=38.6 kDa, expressed in a mammalian expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 250 mM imidazole,and 20% glycerol.
Genbank: NM_000537
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal His-tag
Uniprot: P00797
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Cho, M.J., et al., J Pediatr Endocrinol Metab. 2011; 24(11-12):1085 - 1087
2. Schnermann, J., et al., Kidney Int. 2012 Mar; 81(6): 529 - 538
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