Azido-PEG4-CH2-Boc, CAS 864681-04-9

Product Description: Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG4-CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Applications: Cancer-programmed cell death

Formula: C14H27N3O6

References: [1]Shiladitya Sengupta, et al. Targeted drug delivery through affinity based linkers. WO2015148126A1./[2]Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.

CAS Number: 864681-04-9

Molecular Weight: 333.38

Compound Purity: 97.0

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Linker;PROTAC Linkers

• SKU: MEXHY-42618-1G
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-42618-1G
• Green Labware: No
• Package Unit: 1 g
• Quantity Unit: STK