DC0-NH2, CAS 615538-51-7

Product Description: DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer agents (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component[1].

Applications: Neuroscience-Neuromodulation

Formula: C31H24ClN5O3

References: [1]Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer.J Med Chem. 2012 Jan 26;55(2):766-82.

CAS Number: 615538-51-7

Molecular Weight: 550.01

Compound Purity: 95.00

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: ADC Cytotoxin

• SKU: MEXHY-129379-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-129379-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK