Product Description: DC4SMe, a phosphate proagent of cytotoxic DNA alkylator DC4, can be used in the synthesis of antibody-drug conjugate (ADC). DC4SMe exhibits IC50s of 1.9 nM, 2.9 nM, and 1.8 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC4SMe can be used for the targeted treatment of cancer[1].
Applications: Cancer-programmed cell death
Formula: C35H31ClN5O7PS2
References: [1]Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.
CAS Number: 615538-47-1
Molecular Weight: 764.21
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: ADC Cytotoxin