DM3-SMe, CAS 796073-70-6

Product Description: DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2].

Applications: Cancer-programmed cell death

Formula: C38H54ClN3O10S2

References: [1]Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8)./[2]Yuliang Zhaoet al. Biomedical Nanomaterials. 2016-‎Science.

CAS Number: 796073-70-6

Molecular Weight: 812.43

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Cytotoxin;Microtubule/Tubulin

• SKU: MEXHY-130081-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-130081-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK