DM4-SMe, CAS 796073-68-2

Product Description: DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2].

Applications: Cancer-programmed cell death

Formula: C39H56ClN3O10S2

References: [1]Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73./[2]Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).

CAS Number: 796073-68-2

Molecular Weight: 826.46

Compound Purity: 98.0

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: ADC Cytotoxin;Microtubule/Tubulin

• SKU: MEXHY-130082-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-130082-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK