Duocarmycin A, CAS 118292-34-5

Product Description: Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels[1].

Applications: Cancer-programmed cell death

Formula: C26H25N3O8

References: [1]Hirota M, et al. Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells. Int J Biochem Cell Biol. 2007;39(5):988-96.

CAS Number: 118292-34-5

Molecular Weight: 507.49

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Cytotoxin;Apoptosis;Caspase

• SKU: MEXHY-12455-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-12455-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK