Product Description: Duocarmycin SA is an orally active antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro[2].
Applications: Cancer-programmed cell death
Formula: C25H23N3O7
References: [1]Boyle KE, et.al. Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2688-2692. /[2]Ichimura M,et.al. Duocarmycin SA, a new antitumor antibiotic from Streptomyces sp. J Antibiot (Tokyo). 1990 Aug;43(8):1037-8. /[3]MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6962-5.
CAS Number: 130288-24-3
Molecular Weight: 477.47
Compound Purity: 98.0
Research Area: Cancer
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: ADC Cytotoxin;Antibiotic;Apoptosis;DNA Alkylator/Crosslinker;Necroptosis
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