Dxd, CAS 1599440-33-1

Product Description: Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).

Applications: Cancer-programmed cell death

Formula: C26H24FN3O6

References: [1]Ogitani Y, et al. DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1. Clin Cancer Res. 2016 Oct 15;22(20):5097-5108.

CAS Number: 1599440-33-1

Molecular Weight: 493.48

Compound Purity: 99.37

Research Area: Cancer

Solubility: DMSO : 40 mg/mL (ultrasonic)

Target: ADC Cytotoxin;Topoisomerase

• SKU: MEXHY-13631D-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-13631D-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK