Fmoc-Val-Cit-PAB-PNP, CAS 863971-53-3

Product Description: Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Val-Cit-PAB-PNP has superior plasma stability comparable to that of non-cleavable linkers[1][2][3].

Applications: Cancer-programmed cell death

Formula: C40H42N6O10

References: [1]Dubowchik GM, et al. Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activity. Bioconjug Chem. 2002 Jul-Aug;13(4):855-69. /[2]Yoneda Y, et al. A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1632-6. /[3]Dorywalska M, et al. Effect of attachment site on stability of cleavable antibody drug conjugates. Bioconjug Chem. 2015 Apr 15;26(4):650-9.

CAS Number: 863971-53-3

Molecular Weight: 766.80

Compound Purity: 98.99

Research Area: Cancer

Solubility: DMSO : ≥ 40 mg/mL

Target: ADC Linker

• SKU: MEXHY-41189-250
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-41189-250
• Green Labware: No
• Package Unit: 250 mg
• Quantity Unit: STK