MAC glucuronide phenol-linked SN-38, CAS 2246380-69-6

Product Description: MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) agent linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively.Albumin-coupled MAC glucosidol-linked SN-38 shows good stability in mouse plasma[1][2].

Applications: Cancer-programmed cell death

Formula: C50H54N6O20S

References: [1]Lau UY, et al. Lactone Stabilization is Not a Necessary Feature for Antibody Conjugates of Camptothecins. Mol Pharm. 2018 Sep 4;15(9):4063-4072./[2]Lim JH, et al. Evaluation of In Vivo Prepared Albumin-Drug Conjugate Using Immunoprecipitation Linked LC-MS Assay and Its Application to Mouse Pharmacokinetic Study. Molecules. 2023 Apr 4;28(7):3223.

CAS Number: 2246380-69-6

Molecular Weight: 1091.06

Compound Purity: 99.50

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Drug-Linker Conjugates for ADC

• SKU: MEXHY-128943-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-128943-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK