Mal-PEG2-VCP-Eribulin, CAS 2130869-18-8

Product Description: Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin (HY-13442). Eribulin is a mechanistically unique microtubule inhibitor and Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Mal-PEG2-VCP-Eribulin is an Eribulin-based agent for antibody conjugates[1][2][3].

Applications: Cancer-programmed cell death

Formula: C70H99N7O21

References: [1]Watanabe K, et al. Low-dose eribulin reduces lung metastasis of osteosarcoma in vitro and in vivo. Oncotarget. 2019 Jan 4;10(2):161-174./[2]Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. US20170252458A1./[3]Towle MJ, et al. Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res. 2011 Jan 15;71(2):496-505.

CAS Number: 2130869-18-8

Molecular Weight: 1374.57

Compound Purity: 99.82

Research Area: Cancer

Solubility: DMSO : 10 mg/mL (ultrasonic;warming)

Target: Drug-Linker Conjugates for ADC

• SKU: MEXHY-128870-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-128870-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK