Mc-Val-Cit-PAB-Cl, CAS 1639351-92-0

Product Description: Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).

Applications: Cancer-programmed cell death

Formula: C28H39ClN6O6

References: [1]Staben LR, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041.

CAS Number: 1639351-92-0

Molecular Weight: 591.10

Compound Purity: 95.0

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: ADC Linker

• SKU: MEXHY-112099-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-112099-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK