Mc-Val-Cit-PABC-PNP, CAS 159857-81-5

Product Description: Mc-Val-Cit-PABC-PNP is a cathepsin cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Val-Cit-PABC-PNP can be used in the synthesis of ADCs[1][2].

Applications: Cancer-programmed cell death

Formula: C35H43N7O11

References: [1]Li Y, et al. Discovery of novel antibody-drug conjugates bearing tissue protease specific linker with both anti-angiogenic and strong cytotoxic effects. Bioorg Chem. 2023 Aug;137:106575./[2]Che-Leung Law et al. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders.Patent WO2005081711A2.

CAS Number: 159857-81-5

Molecular Weight: 737.76

Compound Purity: 98.89

Research Area: Cancer; Inflammation/Immunology; Others

Solubility: DMSO : ≥ 37 mg/mL

Target: ADC Linker

• SKU: MEXHY-20336-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-20336-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK