Product Description: Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].
Applications: COVID-19-anti-virus
Formula: C20H20N8Na2O5
References: [1]Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92./[2]Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92./[3]Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund's complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43(5):546-550./[4]Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65(3):168-73.
CAS Number: 7413-34-5
Molecular Weight: 498.40
Compound Purity: 99.71
Research Area: Cancer; Inflammation/Immunology
Solubility: DMSO : 5 mg/mL (ultrasonic;warming;adjust pH to 5 with HCl;heat to 60°C)/H2O : 50 mg/mL (ultrasonic)
Target: ADC Cytotoxin;Antifolate;Apoptosis;Bacterial;DNA/RNA Synthesis
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