Methyltetrazine-PEG4-hydrazone-DBCO

Product Description: Methyltetrazine-PEG4-hydrazone-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Methyltetrazine-PEG4-hydrazone-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-PEG4-hydrazone-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

Applications: Cancer-programmed cell death

Formula: C48H51N9O8

References: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Molecular Weight: 881.97

Compound Purity: 90.0

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Linker

• SKU: MEXHY-136079-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-136079-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK