NAMPT inhibitor-linker 1, CAS 2241019-57-6

Product Description: NAMPT inhibitor-linker 1 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC50s of <3 pM and 9 pM, respectively.

Applications: Cancer-programmed cell death

Formula: C36H37FN6O6

References: [1]Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9(8):838-842.

CAS Number: 2241019-57-6

Molecular Weight: 668.71

Compound Purity: 98.08

Research Area: Cancer

Solubility: DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Drug-Linker Conjugates for ADC

• SKU: MEXHY-112615-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-112615-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK