NAMPT inhibitor-linker 2, CAS 2241014-82-2

Product Description: NAMPT inhibitor-linker 2 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively.

Applications: Cancer-programmed cell death

Formula: C34H33FN6O5

References: [1]Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9(8):838-842.

CAS Number: 2241014-82-2

Molecular Weight: 624.66

Compound Purity: 98.11

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Drug-Linker Conjugates for ADC;NAMPT

• SKU: MEXHY-112616-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-112616-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK