NH2-methylpropanamide-Exatecan (TFA), CAS 1817857-35-4

Product Description: NH2-methylpropanamide-Exatecan TFA is a methylpropanamide-modified Exatecan (HY-13631), which is the common ADC Cytotoxin used in the synthesis of ADC. Exatecan is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1].

Applications: Cancer-programmed cell death

Formula: C30H30F4N4O7

References: [1]Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13(4):950-973.

CAS Number: 1817857-35-4

Molecular Weight: 634.58

Compound Purity: 99.80

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Cytotoxin;Topoisomerase

• SKU: MEXHY-156686-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-156686-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK