PBD dimer-2, CAS 145325-57-1

Product Description: PBD dimer-2 (compound 2c) is a C8-linked pyrrolobenzodiazepine dimer. PBD dimer-2 can span an extra base pair and cross-link the 5′-Pu-GA(T/A)TC-Py sequence. PBD dimer-2 can be used as a payload for antibody–agent conjugates (ADCs), and it can be used for the research of cancer[1][2].

Applications: Cancer-programmed cell death

Formula: C31H36N4O6

References: [1]Smellie M, et al. Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers. Biochemistry. 2003 Jul 15;42(27):8232-9./[2]Staben LR, et al. Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates. J Med Chem. 2020 Sep 10;63(17):9603-9622.

CAS Number: 145325-57-1

Molecular Weight: 560.64

Compound Purity: 98.03

Research Area: Cancer

Solubility: DMSO : 130 mg/mL (ultrasonic)

Target: ADC Cytotoxin

• SKU: MEXHY-148424-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-148424-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK