PBD-monoamide

Product Description: PBD-monoamide, a modified PBD (pyrrolobenzodiazepine) dimer, is an ADC Cytotoxin. PBD-monoamide can be used for synthesis of DHES0815A (an HER2 ADC). PBD-monoamide has DNA-binding activity and reduces cell viability[1].

Applications: Cancer-programmed cell death

Formula: C33H36N4O8

References: [1]Lewis GD, et al. The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results. Nat Commun. 2024 Jan 11;15(1):466.

Molecular Weight: 616.66

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Cytotoxin

• SKU: MEXHY-161252-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161252-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK