PROTAC BRD4 Degrader-12, CAS 2417370-90-0

Product Description: PROTAC BRD4 Degrader-12 (compound 9c) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-12 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.39 nM and 0.24 nM, respectively[1].

Applications: Cancer-programmed cell death

Formula: C62H77F2N9O12S4

References: [1]Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.

CAS Number: 2417370-90-0

Molecular Weight: 1306.58

Compound Purity: 99.85

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Epigenetic Reader Domain;PROTAC-Linker Conjugates for PAC;PROTACs

• SKU: MEXHY-138635-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-138635-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK