S-methyl DM1, CAS 912569-84-7

Product Description: S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin with a Kd of 0.93 μM and inhibts microtubule polymerization. S-methyl DM1 potently suppresses microtubule dynamic instability and has anticancer effects[1][2].

Applications: Cancer-programmed cell death

Formula: C36H50ClN3O10S

References: [1]Lopus M, et al. Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther. 2010 Oct;9(10):2689-99./[2]Oroudjev E, et al. Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability. Mol Cancer Ther. 2010 Oct;9(10):2700-13.

CAS Number: 912569-84-7

Molecular Weight: 752.31

Compound Purity: 99.58

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: ADC Cytotoxin;Microtubule/Tubulin

• SKU: MEXHY-100504-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-100504-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK