Product Description: sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML)[1].
Applications: Cancer-programmed cell death
Formula: C53H60N5NaO12S2
References: [1]Hicks SW, et al. The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models. Haematologica. 2019 Aug;104(8):1633-1639.
CAS Number: 1401203-09-5
Molecular Weight: 1046.19
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: ADC Cytotoxin;DNA Alkylator/Crosslinker