Product Description: Taltobulin (HTI-286), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis[1].
Applications: Cancer-programmed cell death
Formula: C27H43N3O4
References: [1]Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45.
CAS Number: 228266-40-8
Molecular Weight: 473.65
Compound Purity: 99.90
Research Area: Cancer
Solubility: DMSO : ≥ 100 mg/mL
Target: ADC Cytotoxin;Apoptosis;Microtubule/Tubulin
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