TCO-PEG4-DBCO, CAS 1801863-88-6

Product Description: TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. TCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. TCO-PEG4-DBCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

Applications: Cancer-programmed cell death

Formula: C38H49N3O8

References: [1]Rahim MK, et al. Enhancing reactivity for bioorthogonal pretargeting by unmasking antibody-conjugated trans-cyclooctenes. Bioconjug Chem. 2015 Feb 18;26(2):352-60.

CAS Number: 1801863-88-6

Molecular Weight: 675.81

Compound Purity: 99.0

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Linker;PROTAC Linkers

• SKU: MEXHY-140310-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-140310-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK