CloneID: AbAb01-CCP
Heavy Chain modification: Fc Silent™
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted mouse IgG2b Fc Silent™ antibody, based on the original mouse scFv format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: This antibody can detect cyclic citrullinated peptide (CCP), which is a serological marker for rheumatoid arthritis diagnosis. Citrulline is a nonstandard amino acid that is produced by diminution of arginine residue present on certain human proteins by the peptidyl arginine-deiminase (PAD) enzyme. The release of PAD from dying cells citrullinates extracellular proteins that contain arginine. Citrullination appears to be an inflammation-dependent process since it is present in many inflammatory tissues.
Application Notes (Clone): This antibody can be used for the detection of cyclic citrullinated peptides in a sample using ELISA (CN110272497).
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