CloneID: 1H16-B
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing BALB/c mice with his-tagged human syndecan 1 protein.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P18827
Specificity Statement: This antibody binds human syndecan-1. Syndecan-1 is a cell membrane protein that, after its shedding by heparanase enzymes, is accumulated in the extracellular matrix of some tumors, e.g. myeloma and lung carcinoma, where it modulates several key processes of tumorigenesis such as cancer cell proliferation and apoptosis, angiogenesis and metastasis.
Application Notes (Clone): The binding characterization of this antibody for human syndecan 1 was done using ELISA (CN112279917).
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