CloneID: FR1-H7
Antigen Long Description: The original antibody was raised by panning a fab library against FGFR-1(IIIb).
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P11362
Specificity Statement: This antibody is specific for human FGFR-1(IIIb) and FGFR-1(IIIc).
Application Notes (Clone): The original antibody was used for a co-culture proliferation assay on HUVEC-Akt cells. It showed a decrease in cell proliferation (Ding et al., 2015; PMID:26116571). This antibody was used for an ELISA on FGFR-1. Here is showed binding to FGFR-1(IIIb) and FGFR-1(IIIc). This antibody was used for immunoprecipitation on FGFR-1. Where it showed similair results to the ELISA. This antibody was used in vivo on nude mice. The effect of the antibody was significant weight reduction within 48 hours (US8263074B2).
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