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Applications: Useful for the flow cytometry analysis of human GPRC5D.
Assay Conditions: One million of GPRC5D CHO cells (BPS Bioscience #78337) (green) and CHO-K1 cells (blue) were incubated with 1 µg of Anti-GPRC5D Antibody (BPS Bioscience #102000) for 30 minutes on ice. Cells were washed three times, then stained with Goat anti-Human IgG Fc Secondary Antibody, PE, eBioscience™ (Invitrogen #12-4998-82), washed three times, and analyzed by flow cytometry. The Y-axis represents the cell count. The X-axis indicates PE intensity.
Background: GPRC5D (G protein-coupled receptor class C group 5 member D) is an orphan receptor of little-known function belonging to the large family of G protein-coupled receptors. The protein is highly expressed in malignant plasma cells such multiple myeloma and is now considered a therapeutic target for antibody-based treatment of multiple myeloma. For example, CAR-T cells and GPCR5DxCD3 bispecific antibodies resulted in promising outcomes at levels well tolerated by the patients.
Description: This anti-GPRC5D (G protein-coupled receptor class C group 5 member D) antibody is a purified, recombinant monoclonal antibody that recognizes human GPRC5D. The heavy chain construct includes a C-terminal Fc domain. This antibody has been tested for specific binding to human GPRC5D by flow cytometry.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Host Cell Line: HEK293
Purity: ≥90%
Storage Stability: At least 12 months at -80°C.
Uniprot: Q9NZD1
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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