CloneID: A8
Antigen Long Description: The original antibody was generated by immunizing alpacas with human IgA, creating the appropriate phage display library, and panning against the original target.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a chimeric antibody, developed from the original camelid VHH antibody, specifically engineered for enhanced compatibility with existing reagents, assays, and techniques.
Specificity Statement: This antibody is specific for human IgA. It has been observed to have a weak cross-reactivity with human IgG and no cross-reactivity with mouse IgG.
Application Notes (Clone): The binding specificity and affinity of the original camelid (alpaca) single-domain antibody (sdAb; VHH) were tested in an ELISA. It exhibited a high affinity for human IgA and a low affinity for human IgG. This antibody was used to generate an anti-human IgA and anti-avian influenza nucleoprotein bi-specific construct together with Ab04650 [A65], and their stability in vivo was compared (CN111116752B).
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