CloneID: 4.43
Antigen Long Description: The original antibody was generated by immunizing a male llama with recombinant human IGFBP7 protein (Genbank BC017201). An immune llama library was developed and the antibody was isolated by panning against purified human IGFBP7 protein.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a chimeric antibody, developed from the original camelid VHH antibody, specifically engineered for enhanced compatibility with existing reagents, assays, and techniques.
Uniprot Accession No.: Q16270
Specificity Statement: This antibody binds human IGFBP7, also known as IGFBP-related protein 1, is a 31 kDa secreted protein that share structural homology with a family of IGFBP-related proteins. It binds IGF-I and IGF-II with a relatively low affinity and stimulates prostacyclin (PGI2) production. Several studies demonstrated that IGFBP7 is overexpressed in tumor blood vessels with little or no expression in normal blood vessels nor in the non-malignant angiogenic placental tissues.
Application Notes (Clone): The
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