CloneID: JUN1
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing mice with three doses of recombinant lymphocytic choriomeningitis virus (rLCMV)/JUNV-GP and boosted with a final dose of a live attenuated vaccine, Candid#1.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P26313
Specificity Statement: This antibody binds the TfR1 binding site in the GP1 subunit of the envelope glycoprotein of Junin virus (JUNV). Junin virus also known as Argentinian mammarenavirus is an arenavirus in the Mammarenavirus genus which causes Argentine Hemorrhagic Fever (AHF). Mammarenaviruses sporadically cause zoonotic infections in humans, which may lead to life-threatening viral hemorrhagic fever (VHF) disease. VHFs caused by arenaviruses are acute diseases with considerable mortality rates. Symptoms are fever, malaise, headache, nausea, diarrhea, petechial hemorrhage of the soft tissues, lethargy, and irritability. Members of the Arenaviridae family are enveloped viruses with a bi-partite RNA genome coding for four viral proteins. The virus is spread through the aerosolization of host rodent excreta.
Application Notes (Clone): This antibody is highly specific for binding to Junin virus and does not cross react with Machupo virus. This antibody is capable of binding JUNV in an ELISA. This antibody neutralized HIV-1-based virus particles, pseudotyped with full-length JUNV GP and rLCMV/JUNV-GP chimeric viruses in an in vitro neutralization assay (PMID: 35315691).
English
Deutsch
