CloneID: MuSK #13
Heavy Chain modification: Fc Silent™
Antigen Long Description: This antibody was raised by immunizing mice with human MuSK.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted mouse IgG2a Fc Silent™ antibody, based on the original mouse IgG2a format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: O15146
Specificity Statement: This antibody is specific for human MuSK.
Application Notes (Clone): The original antibody was used in vitro to test if it could activate its target. It showed to be a potent MuSK activator. The antibody was also tested in vivo on mice. Here is was shown to localize to the neuromuscular junctions here it increased innervation. This antibody did not show any delay in onset of ALS symptoms (Sengupta-Ghosh et al., 2019; PMID:30528255).
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