CloneID: 4C7
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing mice with a hapten made by covalently conjugating 2-(2-(4-aminophenylsulfonamido)thiazol-5-yl)acetic acid (TS) with BSA.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: This antibody shows high sensitivity for detection of sulfamethizole (SMT) and sulfathiazole (STZ). It also has good sensitivity for detection of sulfachloropyridazine (SCP), sulfamethoxypyridazine (SMP), sulfamethoxazole (SMX), sulfaquinoxaline (SQX), sulfadoxine (SDM), sulfadimethoxypyrimidine (SDT) and sulfamoxole (SXL). Sulfonamides are synthetic bacteriostatic antibiotics that competitively inhibit conversion of p-aminobenzoic acid todihydropteroate, which bacteria need for folate synthesis and ultimately purine and DNA synthesis.
Application Notes (Clone): The binding reactivity of this antibody for various sulphonamide drugs was determined using ELISA (PMID: 23417550). The binding affinity of this antibody towards various sulphonamide drugs is listed in table 1 of PMID: 30580515.
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