CloneID: h1601-008
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was raised by humanizing the heavy and light chain of antibody 1601.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG4 format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P00734
Specificity Statement: This antibody is specific for human thrombin.
Application Notes (Clone): The original antibody was used for an ELISA on human thrombin to determine the binding activity. This antibody was used for surface plasmon resonance on human thrombin. The antibody showed good affinity. The effect of this antibody on thrombinase activity was determined. It showed that it did not inhibit the enzymatic activity of thrombin on substrate S2228. This antibody was used for a human plasma APTT test, it showed increasing APTT values with increasing antibody concentrations. This antibody was tested in vivo. The antibodies were administered to cynomolgus monkeys, they significantly inhibited the formation of thrombosis (US20190315886A1).
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