Abatacept, CAS 332348-12-6

Product Description: Abatacept (CTLA4lg) is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains)[1]. Abatacept is a selective T-cell co-stimulation modulator and a protein agent for the autoimmune diseases[1][2][3].

Applications: COVID-19-immunoregulation

Formula: N/A

References: [1]Patakas A, et al. Abatacept Inhibition of T Cell Priming in Mice by Induction of a Unique Transcriptional Profile That Reduces Their Ability to Activate Antigen-Presenting Cells. Arthritis Rheumatol. 2016 Mar;68(3):627-38./[2]Kiykim A, et al. Abatacept as a Long-Term Targeted Therapy for LRBA Deficiency. J Allergy Clin Immunol Pract. 2019 Jun 22./[3]Lon HK, et al. Modeling pharmacokinetics/pharmacodynamics of abatacept and disease progression in collagen-induced arthritic rats: a population approach. J Pharmacokinet Pharmacodyn. 2013 Dec;40(6):701-12.

CAS Number: 332348-12-6

Molecular Weight: N/A

Compound Purity: 99.0

Research Area: Inflammation/Immunology; Cancer

Solubility: H2O

Target: CTLA-4

• SKU: MEXHY-108829-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-108829-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK