Anti-PD-1 (5C4.B8 (Nivolumab))

Anti-PD-1 [5C4.B8 (Nivolumab)], Monoclonal, IgG1, kappa, Host: Human

CloneID: 5C4.B8 (Nivolumab)

Antigen Long Description: mAb PD1.5 was prepared by immunizing IgH and IgK knock-out transgenic mice possessing a human immunoglobulin (heavy chain) minilocus with recombinant human PD-1-Fc protein consisting of the extracellular domain of PD-1 (amino acids 1–167) and the Fc portion of human IgG1, and Chinese hamster ovary (CHO) cells expressing human PD-1. Nivolumab was generated by grafting the variable regions of PD1.5 onto human kappa and IgG4 constant regions containing an S228P mutation (prevents Fab arm exchange with endogenous IgG4 antibodies).

Buffer Composition: PBS only.

Concentration: 1 mg/ml

Uniprot Accession No.: Q15116

• SKU: ABAAb00791-10.0-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab00791-10.0-BT
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human, Cynomolgus Monkey (Primate)
• Clonality: Monoclonal
• Application: Flow Cytometry, Immunohistochemistry, Blocking, Super-Resolution Microscopy
• Isotype: IgG1
• Host: Human