Benufutamab, CAS 2109730-69-8

Product Description: Benufutamab (GEN1029) is a death receptor 5 (DR5)-specific agonistic antibody. Benufutamab is a mixture of 2 noncompeting DR5-specific IgG1 antibodies, each with an E430G mutation in the Fc domain. Benufutamab has antitumor effects[1].

Applications: Cancer-programmed cell death

Formula: N/A

References: [1]Hilma J van der Horst, et al. Potent preclinical activity of HexaBody-DR5/DR5 in relapsed and/or refractory multiple myeloma. Blood Adv. 2021 Apr 27;5(8):2165-2172. /[2]Marije B Overdijk, et al. Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism. Mol Cancer Ther. 2020 Oct;19(10):2126-2138.

CAS Number: 2109730-69-8

Molecular Weight: N/A

Compound Purity: 98.62

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;TNF Receptor

• SKU: MEXHY-P99470-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P99470-10
• Package Unit: 10 mg
• Quantity Unit: STK
• Conjugate: Unconjugated